Sanguis Draconis (SD), ''Dragon's Blood'', is a resin that is obtained from Daemonorops draco (Palmae). Used in traditional medicine, it has shown activity in the prevention of osteoporosis as well as promoting the healing of bone fractures.
Oh. SDEE means dragon's blood extracted by ethanol solution.
This means that SDEE doesn't just grow cells, it matures them. ALP is a key enzyme that triggers mineralization.
This means that cells weren't just differentiating, they were forming bone matrix. Verified via Alizarin Red and von Kossa staining.
Explaining the staining, they dyed cells to see if dragons blood affected bone matrix.
Here, it is stating that BMP-2 and runx2, which are like switches for bone formation, when under Dragon's blood, it "flips" these switches. It accelerates bone cell programming.
In conclusion: Dragon's Blood... Boosts osteoblast growth Triggers key bone enzymes Enhances matrix mineralization Activates BMP-2 → Runx2 → OCN cascade Supports early-stage bone healing potential Next Steps? We're watching this. I will be experimenting soon. If standardized correctly, it could be a huge osteo-supportive nutraceutical, which would boost chewing, gym bone gains and general bone health so they stay strong even at old age.
There is a protein in the bone matrix known as osteocalcin (OCN)
This protein is produced with age and has an impact in determining endochondral ossification, the process where growth cartilage is replaced with bone
Now, in this study we see how KO mice (Knockout Mice (where mice are completely missing a specific thing being tested, in this case OCN)) who are missing OCN have much longer growth cartilage and the ossification is also delayed.
This leads to potential increase in final height.
This study claims that osteocalcin is present in the condyles as well.
And as we know from a very impactful study we've seen. The condyles still have hypertrophic growth cartilage present well into adulthood.
Now here comes the mindblowing part.
This was from the dragon blood (Daemonorops Draco) study
Not only did the study show an increase in BMP2 and RNX2, which are vital for bone formation, but it also surprisingly decreased the production of OCN, the protein that plays a role in the ossification of growth cartilage.
This leads to the following theory: Dragon's blood, specifically Daemonorops Draco, can not only increase osteoblastic activity and decrease osteoclastic activity for better and faster bone formation, but it can also delay the ossification of the cartilage in the condyles, which can give us more leeway into growing our mandibles much more freely.